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However, in a Canadian proof-of-principle, double-blind, randomised, placebo-controlled study (NCT02141035) in 20 patients with severe carpal tunnel syndrome, acetyl-l-carnitine did not improve nerve regeneration or functional recovery following surgery

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Furthermore, Western blot results also indicated that the supernatant of tumor cells treated with NP4 promoted TRPM2 protein expression in macrophages (Fig