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Most peptides follow a logarithmic dose-response curve: initial dose increases produce large effects, but further increases yield diminishing returns and increasing side effects
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Astragaloside IV can inhibit the phosphorylation of the mTOR signaling pathway, downregulate the Bcl-6 transcription factor in Tfh, and upregulate the CTLA-4 expression in T follicular regulatory cells (Tfr), thereby reshaping the Tfh/Tfr balance to reduce the release of pro-inflammatory factors such as IL-21
This might explain why Candida can cause symptoms that feel like a hangover
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