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By Lana Pine | Published on December 17, 2025 4 min read A large real-world study published in Neurology found that people with Type 2 diabetes taking glucagon-like peptide-1 (GLP-1) receptor agonists had a lower risk of developing epilepsy than those taking dipeptidyl peptidase-4 (DPP-4) inhibitors

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The function of metformin in upregulating GLP-1R level and PKA phosphorylation in endothelial cells may contribute to the synergistic protective effect of this combination therapy, which provides new insights on the interaction between metformin and GLP-1 agents (Fig

FIGURE 4 Importantly, the observed heterogeneity across individual GLP-1 receptor agonists suggests that potential oncological effects may not be uniform across the class

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