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New GLP-1 drugs have emerged, including Eli Lillys tirzepatide (Mounjaro for diabetes, Zepbound for obesity), which activates both GLP-1 and GIP receptors and has produced even greater weight loss than semaglutide

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Step 2: Calculate your draw volume

However, in October 2023, Pfizer discontinued its other oral GLP-1 candidate, lotiglipron, due to elevated liver enzymes observed in clinical trials

If appetite is low: Eat half now and half later

Initiating treatment during relatively stable periods allows better focus on adapting to the medication and establishing supportive routines