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The subcutaneous injection introduces a small volume of solution into the tissue beneath the skin, which can cause mechanical tissue distension and activate local nociceptors

semaglutide (Wegovy) and tirzepatide (Mounjaro) are not currently licensed for use in under-18s for weight management

This practice is generally discouraged for several reasons

Quick Answer: Semaglutide does not typically cause increased urination as a direct side effect according to FDA prescribing information

Importantly, do not discontinue GLP-1 or GIP/GLP-1 therapy solely to donate blood

For the treatment policy estimand, continuous endpoint analyses were conducted with the use of the analysis-of-covariance method, with randomized treatment as a factor and baseline endpoint value as a covariate