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Thymosin Alpha-1, for example, has a plasma half-life of approximately 2 hours but exerts immunomodulatory effects for considerably longer periods, likely because of downstream signaling cascades that persist well beyond peptide clearance

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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

doi: 10.1016/j.ejphar.2018.01.037 54 MatthysPHatseSVermeireKWuytsABridgerGHensonGWet al

While they are frequently stacked together, they operate through distinct molecular pathways