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Genetic polymorphisms in drug-metabolizing enzymes further complicate toxicity profiles

Mounjaro (tirzepatide) is a prescription medication licensed by the MHRA for the treatment of type 2 diabetes mellitus and for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity

Cysteine and glycine are both necessary precursors for glutathione (GSH) synthesis, and co-supplementation of these nutrients promotes intracellular glutathione levels

Patients were also advised not to take any oral antioxidant and multi-vitamin supplements

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doi: 10.1016/j.neuropharm.2020.108026 29