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The clinical relevance of these results seems also highlighted by the evidence that for some outcomes the clinical benefit is consistent irrespective of the presence of type 2 diabetes [13], advanced age [13, 30], and the background cardiorenal disease [12, 15, 31]

The lack of nutrients also leads to the depletion of reducing agents like glutathione and thus to the overall reduction of antioxidative capacity in hepatocytes

Nature , 420 , 860867

This can lead to low energy levels

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