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ROS are mainly produced in mitochondria during aerobic respiration, especially at complexes I and III of the electron transport chain [162, 163]

Targeting c-Met has been investigated in anti-EGFR resistant cells because c-Met is a key player in anti-EGFR resistance [148]

Copper tripeptide-1 (also called GHK-Cu or glycyl-histidyl-lysine peptide) links three of these amino acids together with copper enzymes

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However, often such treatments have dangerous side-effects and concerns over long-term use

Abstract This study aimed to develop a non-genetically modified organism (non-GMO) Saccharomyces cerevisiae strain with enhanced glutathione production using UV-induced random mutagenesis