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Keywords: neuroinflammation, major depressive disorder, cytokines, microglia, astrocytes, neurotransmitters, neurotoxicity, hypothalamicpituitaryadrenal axis 1

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The Supplementary Table, below, shows the demographic representation by category in Phase 3 trials supported by NIH centers and institutes

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Visible changes usually appear in 4 to 6 weeks

These findings position the compound as a valuable research tool for investigating whether NNMT modulation influences age-associated metabolic changes in mammalian aging models