(Research has identified mast cells as one of the immune cell types involved in the inflammatory cascades that influence arterial plaque development and lipid-related cardiovascular risk, as I note in my MCAS info page.) In neurological disease , research in animal models of stroke and vascular dementia has shown that GLP-1RAs reduce both microglial activation and neuroinflammation, leading to better protection of the brain from injury and cognitive deterioration
Last updated January 10, 2026.
Across 10 studies, the incidence of thyroid cancer was less than 1%, which suggests that there is no significant risk of thyroid cancer associated with semaglutide use in humans
It's slow, steady work over many, many years
This did not reach a significant threshold and is not included on the various product labels, but it is reasonable to consider that some patients may alter their diet drastically while taking semaglutide and should ensure they get foods rich in iron and B12
This trial showed approximately 20% reduction in cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke compared to placebo