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Single nucleotide variations in the C13orf31 gene , resulting in amino acid changes in p.C284R and p.I254V in a protein of unidentified function, play a role in the development of systemic juvenile idiopathic arthritis and are associated with heightened susceptibility to leprosy and CD (66).This suggests that individuals with IBD may have an inherent vulnerability to mitochondrial dysfunction, particularly influenced by the gut environment

CAT is overexpressed in multiple cancer types, including gastric cancer, colon cancer, melanoma, and leukemia [40,41,42,43]

Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase

BPC-157 BPC-157

Animal studies support enzyme inhibition, but human in vivo evidence remains inconsistent

2010), impairment of its activity (Park et al