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In this experiment, expression of gene-level and transcript-level were both decreased, but enzyme activity of GPX represent no significant change

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Consistent with enhanced glutathione production, melatonin-treated ILC2s exhibited increased expression of GCLC and GCLM, enzymes that catalyze the rate-limiting steps in glutathione synthesis ( Figures 6E, F )

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Folia Neuropathol 55:199205 Semnani M-R, Mashayekhi F, Azarnia M, Salehi Z (2016) Effects of green tea epigallocatechin-3-gallate (EGCG) on proteolipid protein (PLP) and oligodendrocyte transcription factor 1 (Olig1) expression in the cerebral cortex of cuprizone induced multiple sclerosis mice