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K + balance and water homeostasis are maintained through Kir4.1 and AQP4 channels, respectively, which are localized at the perivascular endfeet 108,109

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Since both melanocytes and Schwann cells arise from the neural crest, it was previously hypothesized by Masson [] that naevus cells in the upper dermis originate from melanocytes, whereas those in the lower dermis originate from Schwann cells

these are mainly situations where erythrocyte turnover is altered or in the presence of haemoglobinopathies (Table 4) [67]

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This cascade ultimately leads to ROS production and DNA damage, culminating in cardiomyocyte proliferation arrest and embryonic death [69]