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Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression

Thus, ectopic endometrial tissue might shift the threshold at which ferroptosis occurs by metabolic reprogramming towards a proliferative advantage for itself, something that seems to be similar to that of cancer cells

O., et al

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Genes up/down-regulated in these knockdown cells were only partially overlapped, consistent with the notion that they regulate several biological pathways (e.g., TRIP12 regulates cell cycle progression and chromatin remodeling 24 , while UBR5 regulates DNA replication and protein quality control 36,37 )