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Rif-treated (blue) and infected (white) macrophages served as controls (n = 3, two-sided unpaired t-test)

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Ero1 can be oxidized rapidly in the presence of flavin adenine dinucleotide (FAD) and oxygen, indicating that oxygen is the ultimate electron acceptor (Tu & Weissman, 2002)

For these peptides to remain effective in vivo, their digestion products must also retain the ability to inhibit DPP-IV