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However, split dosing (0.25 mg every 12 hours rather than 0.5 mg once daily) may provide more consistent tissue exposure throughout the day

After the 26-week treatment period, the mean percentage of weight reduction from baseline was greater with all doses of cagrilintide (0.34.5 mg, 6.0%10.8%) versus placebo (3.0%)

Avoid high-fat and high-sugar meals, which can worsen GI side effects

It is naturally produced in the gut in response to food intake and helps stimulate insulin secretion while slowing gastric emptying

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