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These findings, together with the very low plasma concentrations of Ang A, do not provide evidence for a physiological role of Ang A as a naturally occurring peptide, possibly counteracting the Ang II-mediated vasoconstrictor effects

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However comments, even when ill-informed, create impact if broadcast loud enough and its important to understand sentiment at the broadest level as well as at the informed level, because it will affect potential patients view of obesity as a disease, their desire to use these agents, and the likelihood that they do go down the path to pharmacotherapy (as well as potentially their experience when on it)

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