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Age As individuals age, the body's ability to absorb vitamin B12 declines

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In the absence of myelin, redistribution of Na + occurs to maintain the transmission of nerve impulses that increases energy demand, and this produces a situation of virtual hypoxia. At the end, the demand exceeds the capacity of axonal mitochondria to produce enough ATP, which causes an increase in the concentration of Ca 2+ in the axon

11 JiangJ.ZouY.XieC.YangM.TongQ.YuanM.et al (2023)

5 ResearchGate (2021)Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice