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Explore the CVOT study for RYBELSUS PIONEER 6: cardiovascular safety 6,7 Study design: In a double-blind trial, 3183 adult patients with inadequately controlled type 2 diabetes at high CV risk (50 years of age with CVD or CKD, or 60 with at least 1 CV risk factor) were randomized to RYBELSUS 14 mg (n=1591) or placebo (n=1592), both once daily and in addition to standard of care for a median observation time of 16 months

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Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter

Understanding these mechanisms could help manage dyslipidemia and cardiovascular risk [62]