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Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]

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10.1016/j.exer.2015.04.016 43 Medvidovic-GrubisicM.StambolijaV.KolencD.KatancicJ.MurselovicT.Plestina-BorjanI.et al (2017)

[257] This difference in mechanism generally results in fewer side effects and less risk of tolerance or dependence

While many studies focus on defining the activation state and function of immune cells in isolation, it is important to take the downstream consequences of these immunologic changes into consideration

During the conversation, Jameel Akhter, co-founder of Startup Pedia and podcast host, questioned people's obsession with fairness creams and whether these products truly make someone fair and lovely