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Heterogeneities were assessed within and between study designs for Africa (I 2 = 99.3%, p = 0.001), America (I 2 = 83.4%, p = 0.001), Asia (I 2 = 97.6%, p = 0.001), Europe (I 2 = 94.1%, p = 0.001), and overall (I 2 = 96.4%, p = 0.001) (Fig

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Key principles include: The ability of stem cells to self-renew and differentiate

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More importantly, greater emphasis should be placed on studying their molecular mechanisms, especially their effects on inflammatory pathways and oxidative stress, to develop more targeted therapeutic approaches