Back to Journals Neuropsychiatric Disease and Treatment Volume 22 Current Evidence of Acetyl-L-Carnitine Use in Mood Disorders-: A Systematic Review and Meta-Analysis Authors Kumar R , Hashempour Z, Shahriarirad S, Shahriarirad R, Hassett LC, Singh B , Croarkin PE , Veldic M, Frye MA, Pagali SR Received 6 January 2026 Accepted for publication 12 March 2026 Published 3 June 2026 Volume 2026:22 586506 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Roger Pinder Rakesh Kumar, 1 Zahra Hashempour, 2 Sara Shahriarirad, 2 Reza Shahriarirad, 3 Leslie C Hassett, 4 Balwinder Singh, 1 Paul E Croarkin, 1 Marin Veldic, 1 Mark A Frye, 1 Sandeep R Pagali 5 1 Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA
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While they are known to exhibit beneficial roles in some cellular processes, superoxide free radicals also possess the ability to initiate a cascade of ROS and free-radical species formation in biological systems
This was expected, and researchers say that in a real clinical transplant, standard drugs could help manage this later response
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