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After 4 to 6 weeks, the dose can be increased to 1.0 mg if tolerated well

Were going to get into this in more depth later, but remember that the cardiovascular trial rode to FDA approval on the back of an extremely ethically questionable publicity stunt and the benefit was a 1.5% absolute risk reduction that was not statistically significant for women, Black people, Hispanic people, those under 55 or over 75, and those with a BMI above 35

The use of Insulin Glargine, U-300 for this indication is supported by evidence from an adequate and well-controlled study in 463 pediatric patients 6 to 17 years of age with type 1 diabetes mellitus [see Clinical Studies (14.2)] and from studies in adults with diabetes mellitus [see Clinical Pharmacology (12.3), Clinical Studies (14.3)]

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