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The secondary structure of GST includes alpha helices and beta sheets that are arranged in a manner typical of the GST family of enzymes

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Given that salivary glands express GLP-1R at low but detectable levels, chronic overstimulation could plausibly extend these adverse patterns to oral secretory dysfunction

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A dedicated cardiovascular outcomes trial (CVOT) for orforglipron has not been mandated by the FDA for initial approval but may be required or conducted voluntarily as a post-marketing commitment, following the precedent set by the SELECT trial for semaglutide

Additionally, injections can be given twice a week if deemed appropriate