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Protocatechuate is then ring-cleaved by either the ortho (3,4-dioxygenase) or meta (4,5-dioxygenase) pathway, generating -carboxy-cis,cis-muconate or its meta-cleavage analogue, which feed through -ketoadipate or pyruvate/oxaloacetate intermediates into the TCA cycle

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Perez-Hernandez, G., Paul, F., Giorgino, T., De Fabritiis, G