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Its therapeutic effects in this setting include: acute anaphylactic reactions beta-2 mediated bronchodilation beta-2 mediated decrease in release of inflammatory mediators by mast cells & basophils (Peachell 2006) alpha-1 & alpha-2 mediated vasoconstriction & resulting decrease of mucosal edema in the upper airway increased blood pressure (to counteract histamine-induced hypotension) e.g

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The formation of metal-flavonoid complexes significantly enhances their bioavailability, positioning these compounds as promising candidates for next-generation therapeutics ( Ehretia tinifolia extract (ETME) counteracts this response by activating the protective Nrf2/HO-1 pathway while suppressing NF-B/MAPK-mediated inflammation

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The enzyme responsible for producing melanin is called tyrosinase