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In wound infections, TLR signaling is activated by PAMPs such as lipopolysaccharides (TLR4 ligands), lipoteichoic acid (TLR2 ligands), flagellin (TLR5 ligand), and unmethylated CpG DNA (TLR9 ligand) derived from invading bacteria, fungi, or viruses [32]
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However, levels can be depleted by age, stress, and environmental factors
Furthermore, this study delineated the efficacy, safety, and prospective avenues of acupuncture in the treatment of RP
These fatty acids can reduce the production of pro-inflammatory cytokines and eicosanoids, thereby mitigating inflammation and promoting a more favorable environment for tissue repair
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