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Inflammatory mediators can cross the bloodbrain barrier, activating the microglia and leading to the release of neurotoxic factors with adverse effects on dopaminergic neurons [21]

If the excursion was brief (under 6 hours) and temperature remained below 20C, the peptide may retain partial potency, but this introduces unacceptable variability into experimental protocols

3 In the REIMAGINE 1 trial, the most commonly reported adverse events (AEs) were gastrointestinal (GI)-related, occurring in 33/62 (53%) participants in the CagriSema 2.4 mg/2.4 mg group, 28/63 (44%) participants in the CagriSema 1 mg/1 mg group, and 13/64 (20%) participants in the placebo group

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10.1111/j.1471-4159.2006.04393.x 69