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Facial fat has excellent blood supply and is metabolically active, so your body mobilizes it early during calorie deficit

Only 5 patients stopped the trial from gastrointestinal side effects and only 5% of the 9mg and 12mg arms had to stop the trial for any adverse events

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Hiraiwa T, Ito M, Imagawa A, Takamatsu J, Kuma K, Miyauchi A et al (2006) Restriction of dietary Iodine does not ameliorate the early effect of anti-thyroid drug therapy for Graves disease in an area of excessive iodine intake

However, other reports supported an inverse relationship 35,36,37,38