On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins
Hypothyroid animals also have prolonged wound healing due to increased mast cells.[ref][ref][ref] Related article: Thyroid hormones, genetics, and hypothyroidism Asthma and mast cell activation: Mast cells are abundant near the epithelial cells lining the lungs
Some people experience modest weight loss in the first few months due to appetite suppression, whilst others may gain weight or return to baseline after six months to a year of treatment as the body adjusts or depression symptoms improve
doi: 10.1016/j.cgh.2023.05.027
These adverse effects stem from the entry of the cytoplasmic exonuclease TREX1 into the nucleus, which induces DNA cleavage [195], as well as the translocation of DNA repair factors such as Ku70, Ku80, and BRCA1 to the cytoplasm [190, 194]
Physiological adaptations Hormonal changes - hormonal changes during pregnancy help to direct nutrients to the developing fetus