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Assessing sustained treatment effects is particularly challenging in a database like the US Renal Data System, in which detailed follow-up data on key clinical variables are limited for making the assessment of treatment initiation effects valid for this population

13,53,204,205,206 Disturbances in lipid metabolism contribute to neuronal apoptosis, while insulin resistance and deficiencies in neurotrophic factors impede nerve regeneration

Geronzi et al., 2018)

In response to various brain stresses, astrocytes undergo functional and morphological changes, either signaling the immune system or directly mitigating damage within the brain