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SIRT1, a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase, can promote mitochondrial biogenesis by activating PGC-1 37,38

While the use of oncogene-driven mouse models has been helpful in linking specific genomic alterations with aberrant metabolic phenotypes in some tumor types (100103), the profound number of molecular aberrations and heterogeneity observed in human tumors make it challenging to identify single DNA or gene alterations that dictate metabolic regulation

Ben Abdallah F, Dammak I, Attia H, Hentati B, Ammar-Keskes L: Lipid peroxidation and antioxidant enzyme activities in infertile men: correlation with semen parameter

Acetyl L-carnitine is distinguished by its particular stability

To generate litters, two females were mated with one male in our facility