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Importantly, while RCTs consistently demonstrate robust short-term glycemic improvements, real-world data suggest that long-term treatment continuity remains a major challenge

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In combination with weight loss, muscle mass loss can concurrently occur when taking Semaglutide and Tirzepatide

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Long-term management strategies: Slow dose escalation (extend any phase if needed) Take medication with food Avoid high-fat meals during dose increases Stay hydrated Over-the-counter anti-nausea aids (ginger, vitamin B6) For comprehensive side effect management information, see our complete side effects guide