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In further experiments, four insomniac patients adapted in the laboratory for 1 night, with placebo injections for 2 nights, were treated continuously for 4 days with DSIP administered 1 hour before bedtime
The maximum total dose currently recommended to be given in the ED is 16 mg, however, studies are ongoing exploring giving higher total doses up to 32 mg9
Upon the upregulation and activation of Nrf2, the heterodimers of nuclear Nrf2 and small Maf proteins form to recognize antioxidant response elements (AREs), and then recruit key factors for transcription of Nrf2 target gene including HO-1 (Hayes et al., 2010)
It means precision matters more outside controlled environments
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