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This is because active folate (methylfolate) is required for B12-dependent reactions, and MTHFR variants can reduce folate availability

D., et al

Are MIC B12 injections safe for people with diabetes or thyroid conditions? MIC B12 injections do not directly interact with diabetes medications or thyroid hormone replacement, but patients with these conditions should consult their prescribing physician before starting

Start with small portions and listen to your body

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What Does Vitamin B12 Do for You