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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

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Int J Mol Sci 23(16):9138 Lo CC et al (2024) Associations of the gut microbiome with neuroimaging markers of glymphatic dysfunction and cognitive functions in healthy middle-aged Chinese

However, youll need an ultrasound scan to confirm this