Aug 14: In what is expected to become a multibillion-dollar blockbuster, Pfizers BCMAxCD3 bispecific antibody Elrexfio (elranatamab-bcmm) has secured an FDA accelerated approval as another off-the-shelf treatment option for patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior lines of therapy
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Acknowledgements We thank the Computing Platform of the Center for Life Science for supporting the LCMS/MS data analysis
Marissa Liza: Um, and yes, I, I did the same
Another naturally occurring sphingolipid, sphingosine-1-phosphate, has been shown in vitro to modulate the expression of GPX4 and FPN1, and TFRC, which may contribute to reduce radiation-induced ferroptosis in KGN cells (Zhao et al., 2023)
Similarly, the pro-LOX effect was also identified with androgens, as Harlow et al (100) and Slee et al (101) identified that 5-dihydrotestosterone significantly increased LOX expression levels both in vitro and in vivo
