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Another noteworthy example is -polylysine, which exhibited MIC values of 500, 800, 800, and 1,000 g/mL against P

All D2HGA2 patients that have been identified exhibited developmental delay and to a more severe degree than that seen in D2HGA1 patients

Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis and an oncogenic c-MYC transcriptional target (Bello-Fernandez et al., 2015), indicating that metabolism is a hub that connects development and cancer

McCarty MF, DiNicolantonio JJ

Even if this is the only mitochondrial parameter affected at an earlier point, it could make mitochondria more prone to developing compromised functions as the result of prolonged ART exposure

This includes delivering wild-type LONP1 via adeno-associated virus vectors or employing gene editing to correct pathogenic variants