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The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks

( A ) Mean CellTiter-Glo measurements of A549shNRF2-BIND-luc, -BIND-WT NRF2, -BIND-Neh4/5mut cells treated with water (control) or 2.5 ng/mL dox for 48 h, then treated with indicated concentrations of BSO for 96 h

Involved in cellular signalling and extracellular matrix communication

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