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Body stores can last for two to five years or longer, which is why deficiency often develops slowly and may not become apparent for some time after dietary intake or absorption becomes inadequate

Therefore, GSH itself may not be effective at direct reduction of reactive oxygen species under physiological conditions

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It is suggested that there might be a link between the emergence of this tissue and the heightened activity of antioxidant enzymes

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This connection emphasizes the critical role of the gut-liver-immune axis in the disease process and identifies it as a valuable focus for novel treatments (57)