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This distinction matters for patients with autoimmune disease, inflammatory bowel disease, mast cell symptoms, chronic infections, allergies, or complex immune histories

Autoimmune Diseases Rheumatoid Arthritis (RA) - Some studies have found that individuals with MTHFR polymorphisms, particularly the C677T variant, may have an increased risk of RA, potentially due to altered folate metabolism and immune dysregulation

Some medical conditions or medications can make it less effective or potentially unsafe

Autism Res (2011) 4(4):27182

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These models have been instrumental in advancing our understanding of AD pathology and evaluating the efficacy of therapeutic interventions