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All is good when the ROS produced in the mitochondria is converted appropriately into a non-reactive molecule, and ROS levels are kept in check

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Moreover, NRF2 is required for the survival of hematopoietic stem progenitor cells (HSPCs) and the development of myeloid cells in mice, as NRF2 KO bone marrow had defect in stem cell function and showed reduction of chimerism after transplantation [124]

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