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NICE in the UK recommends a maximum of two years for semaglutide (Wegovy), though no such limit exists for tirzepatide (Mounjaro)

doi: 10.1038/sj.bmt.1701885 123 KandaJMizumotoCKawabataHIchinoheTTsuchidaHTomosugiNet al

Despite the coherence of the early worsening hypothesis, the narrative is further complicated by a large body of real-world evidence that does not reflect the risk signals seen in certain trials

reconstituted material should be refrigerated at 28C and used promptly

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