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Brief discomfort is common with subcutaneous injections

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Amini MR, Sheikhhossein F, Talebyan A, Bazshahi E, Djafari F, Hekmatdoost A

Research has suggested that rapid weight loss from GLP-1 medications can shift fat distribution in ways that affect the sensory nerves near the skin, potentially contributing to sensations like burning, tingling, or increased sensitivity

Notably, only one registered clinical study exists to date, which evaluates an implant-based delivery system of Exenatide and is currently in Phase 1 with an Active, not recruiting status (NCT05670379), initiated on December 20, 2024, and expected to conclude by August 2025

Potential Side Effects and Management Like all medications, semaglutide can cause side effects