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OMA1-DELE1-dependent ISR signaling may also protect against ferroptosis 159 , an iron-dependent form of cell death 160 that is further discussed in the section Mitochondrial iron at the crossroads with human diseases

Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

However, formal pharmacoeconomic analyses comparing these agents to standard drugs are currently lacking and should be prioritized in future research

Clin Sci 91 : 7986

Protects cells from oxidative stress, a key factor in the development of heart disease and cancer

In human cell culture, Jakubowski (1997) showed that the thiolactone produced by an altered homocysteine metabolism may be incorporated into cellular and extracellular protein through lysine acylation by its activated carboxyl group