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Moreover, GIPR deficiency and the application of an antagonistic GIP receptor antibody significantly diminish the levels of pro-inflammatory cytokines such as Il-6 and Socs3 in the hypothalamus in mice [230]

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In contrast, small molecules, as the name suggests, are much smaller than peptides and are easily absorbed

10.3233/JPD-181474 38 DoyleM

To test for differentially activated regulons across treatments, a linear mixed-effects model was constructed with the SCENIC regulon activity score as dependent variable, treatment and time point as independent variables with interaction effects, and mouse and sequencing pool as random effects

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