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GLP-1R agonism has direct cell autonomous anti-apoptotic effects in the rodent heart, and GLP-1 reduces hypoxia-induced apoptosis in isolated neonatal rat cardiomyocytes, and inhibition of PI3K using LY29400 or MAPK using UO126 blocks the anti-apoptotic effect of GLP-1 [615]

Its stability in gastric fluid is a notable characteristic, distinguishing it from many other peptides

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