Adverse psychiatric effects associated with GLP-1 RAs, including depression, anxiety, and suicidal ideation, are noted in pharmacovigilance analyses, with variations among different GLP-1 RAs
The effect can linger into the next day
Exenatide (Byetta and Bydureon, AstraZeneca), is a synthetic 39-amino acid peptide (first discovered as exendin-4 in the saliva of the gila monster, Heloderma suspectum) (Figure 8) [879]
It's noteworthy that these Parkinson-like events following ranibizumab administration are distinguished by the absence of cortical and subcortical atrophy, suggesting a unique pathophysiological mechanism distinct from typical PD presentations (Sultana and Scondotto 2020)
There was, however, a challenge: the half-life of GLP-1 in plasma was only 1-2 minutes
And in rats, tirzepatide causes thyroid C-cell tumors