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Abstract Aims/hypothesis COMBINE 2 assessed the efficacy and safety of once-weekly IcoSema (a combination therapy of basal insulin icodec and semaglutide) vs once-weekly semaglutide (a glucagon-like peptide-1 analogue) 1.0 mg in individuals with type 2 diabetes inadequately managed with GLP-1 receptor agonist (GLP-1 RA) therapy, with or without additional oral glucose-lowering medications

In both the trial-product and treatment-policy estimand analyses, all oral semaglutide groups demonstrated a significantly greater reduction in A1C from baseline when compared with placebo at 26 and 52 weeks